Hydrocephalus is an abnormal build up of cerebral spinal fluid on the brain and can be caused by a variety of factors depending on the age that hydrocephalus develops (Reeves, 2016). X-linked hydrocephalus occurs at birth and is a sex-linked recessive trait. X-linked hydrocephalus is believed to be associated with the L1 cell adhesion molecule (L1cam) gene (Kong 2020). X-linked hydrocephalus is also known as HSAS (X-linked hydrocephalus with stenosis of the aqueduct of Sylvius) and is the most severe of the L1 syndrome diseases (Genetics Home Reference, 2020).
References
Reeves, M. (2016). Hydrocephalus : Prevalence, Risk Factors and Treatment. Nova Science Publishers, Inc
Kong, W., Wang, X., Zhao, J., Kang, M., Xi, N.,& Li, S. (2020). A new frameshift mutation in L1CAM producing X‐linked hydrocephalus. Molecular Genetics & Genomic Medicine, 1. https://doi.org/10.1002/mgg3.1031
Genetics Home Reference. (2020). L1 syndrome. US National Library of Medicine. Retrieved on April 20, 2020 from https://ghr.nlm.nih.gov/condition/l1-syndrome#genes
Reeves, M. (2016). Hydrocephalus : Prevalence, Risk Factors and Treatment. Nova Science Publishers, Inc
Kong, W., Wang, X., Zhao, J., Kang, M., Xi, N.,& Li, S. (2020). A new frameshift mutation in L1CAM producing X‐linked hydrocephalus. Molecular Genetics & Genomic Medicine, 1. https://doi.org/10.1002/mgg3.1031
Genetics Home Reference. (2020). L1 syndrome. US National Library of Medicine. Retrieved on April 20, 2020 from https://ghr.nlm.nih.gov/condition/l1-syndrome#genes
Author
Kaitlyn Main is an undergraduate student at Middle Georgia State University. She created this website as a project for BIOL 4321 - Special Topics: Human Genetics course. All Resources used can be found on the "Reference" page of this website.